Funding

Development and Application of the AMOEBA Polarizable Force Field. National Science Foundation. Aug 2012 - Jul 2016. Award Number: 1152522

New Bioanalytical Methods Based on Next Generation Sequencing. National Institutes of Health. Oct 2014 - Sep 2019. Award Number: 5R01GM109974-02 (Co-Investigator)

Cohesin Dynamics And Transcriptional Enhancer Function. National Institute Of General Medical Sciences. Sep 2015 - Jul 2019. Award Number: 1R01GM108714-01A1 (Co- Investigator)

RNA-dependent RNA Polymerase. National Institute of Allergy and Infectious Diseases. Jul 2015 - Jun 2020. Award Number: R01AI045818-16A1 (Subcontract)

Structural studies of the HBV ribonuclease H. National Institutes of Health. Mar 2016 - Feb 2018. Award Number: 1R03AI123689-01 (Co-Investigator)

Publications

Why ser and not thr brokers catalysis in the trypsin fold. Abstract Pubmed

Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase. Abstract Pubmed

Sequence selectivity of macrolide-induced translational attenuation. Abstract Pubmed

Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. Abstract Pubmed

Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes. Abstract Pubmed

Genome-wide control of RNA polymerase II activity by cohesin. Abstract Pubmed

Conformational selection in trypsin-like proteases. Abstract Pubmed

Genome-wide networks of amino acid covariances are common among viruses. Abstract Pubmed

Allostery in trypsin-like proteases suggests new therapeutic strategies. Abstract Pubmed

OpenCL: A Parallel Programming Standard for Heterogeneous Computing Systems. Abstract Pubmed

APBSmem: a graphical interface for electrostatic calculations at the membrane. Abstract Pubmed

Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. Abstract Pubmed

Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Abstract Pubmed

Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Abstract Pubmed

Manganese-dependent polioviruses caused by mutations within the viral polymerase. Abstract Pubmed

Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. Abstract Pubmed

Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. Abstract Pubmed

Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli. Abstract Pubmed

Book Chapters

Hardy, D., Stone, J., Vandivort, K. and Gohara, D. (2011) Fast Molecular Electrostatics Algorithms on GPUs. GPU Computing Gems. Hwu, W.W., ed. Chapter 4.

Korneeva, V., Gohara D.W., and Cameron, C.E. (2003). The RNA-dependent RNA polymerase: Structure, function and mechanism. In Mechanisms of Replication and Transcription of RNA Viruses. Zhang, X., ed. Research Signpost, Kerala, India, pp. 17-36.

Cameron, C.E., Gohara, D.W., and Arnold, J.J. (2002). Poliovirus RNA-dependent RNA polymerase (3Dpol): Structure, function and mechanism. In Molecular Biology of Picornaviruses. Semler, B.L. and Wimmer, E., eds. ASM Press, Washington, D.C., pp. 255- 267.